李柏村

一、个人信息：

姓名：李柏村

职称：副研究员

学历：博士研究生

二、教育经历：

2007.9-2011.6 中国药科大学基础药学理科基地，学士；

2012.9-2018.6 厦门大学化学生物学专业，博士；

三、主要工作经历：

2018-2022中国医学科学院基础医学研究所 博士后；

2022-至今 中日友好医院国家呼吸医学中心 PI，呼吸和共病全国重点实验室主任；

四、学术成果：

主持的省部级以上课题：

1.十四五重点研究计划：肺纤维化动物模型病理机制解析和新靶标发现，375万元；

2.科技创新2030 ：慢阻肺病呼吸道损伤的演进规律和调节机制，199万元；

3.国家自然科学基金青年项目：核受体Nur77介导气道上皮细胞线粒体稳态失衡在慢性阻塞性肺疾病中的作用与机制研究，30万元；

4.国家自然科学基金面上项目：PDK4/p-PDHE1α调控糖代谢重编程介导的肺泡巨噬细胞稳态失衡促进慢阻肺病进展的机制及靶向干预研究，48万元；

发表的高水平论文：

1. Liu Q, Zhang Y, Duan R, Li W, Hou X, Chen Y, Li B, Yang T. Transcriptome reveals the landscape of alveolar macrophages exposed to combined hypoxia with cigarette smoke extract. Respir Res. 2025 Jul 10;26(1):241

2. You H, Shan J, Bai Y, Yang R, Tan S, Gu Y, Li B# , Wu H# , Liu Y# . CRISPR/Cas-powered “sweet” DNA nano-sponge for highly sensitive detection of pathogen nucleic acid with portable personal glucometer. Chem Eng J, 2025: 160618.

3. Zhou L, Song C, Lei Y, Zhao L, Han Y, Xu Y, Li B# , Guo J# . Health impacts of PM2.5 emissions from brake pad wear: A comprehensive study on pulmonary, metabolic, and microbiota alterations. Toxicology. 2025 Jan 12;511:154055.

4. Zhou L, Song C, Zhao L, Guo Z, Lei Y, Han Y, Gao K, Xu Y, Xiang Z#, Li B# , Guo J# . Impact of variations in airborne microbiota on pneumonia infection: An exploratory study. Ecotoxicol Environ Saf. 2025 Jan 28;291:117795.

5. Chen J, Zhao T, Hong W, Li H, Ao M, Zhong Y, Chen X, Qiu Y, Wang X, Wu Z, Lin T, Li B#., Chen X#., Fang M#.. Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy. Acta Pharm Sin B. 2024 Dec;14(12):5493-5504.

6. Bai, Y.; Tan, S.; Sheng, Y.; Gu, Y.; Wu, H# .; Li, B# .; Liu, Y# . A High-Affinity Methyl-CpG-Binding Protein for Endonuclease-Free and Label-Free DNA Methyltransferase Activity Detection. Journal of Analysis and Testing 2024, 8 (3), 327-334.

7. Yu ZW, Wang J, Lin FH, He FM, Li HS, Wang SS, Fang MJ#, Li B# , Qiu YK# . A comprehensive study on solvent effect and establishment of n-hexane solvent system based normal-phase liquid chromatography × reversed-phase liquid chromatography for isolation of natural products. J Chromatogr A. 2024 Aug 19;1733:465278.

8. Duan R*, Huang K*, Yu T, Chang C, Chu X, Huang Y, Zheng Z, Ma L, Li B# , Yang T# . Interleukin-2/anti-interleukin-2 complex attenuates inflammation in a mouse COPD model by expanding CD4+ CD25+ Foxp3+ regulatory T cells. Int Immunopharmacol. 2024 Mar 18;131:111849.

9. Chang C*, Huang K*, Xu X, Duan R, Yu T, Chu X, Chen C, Li B# , Yang T# . MiR-23a-5p alleviates chronic obstructive pulmonary disease through targeted regulation of RAGE-ROS pathway. Respir Res. 2024 Feb 20;25(1):93.

10. Fang H, Li M, Wang X, Chen W, He F, Zhang Y, Guo K, Jin W, Li B# , Fang M# . Discovery of new DHA ethanolamine derivatives as potential anti-inflammatory agents targeting Nur77. Bioorg Chem. 2023 Sep 28;141:106887.

11. Zhao L*, Li B*, Zhou L*, Song C, Kang T, Xu Y, Liu Y, Han Y, Zhao W, Jia H, Zhang B, Guo J. PM2.5 exposure promotes asthma in aged Brown-Norway rats: Implication of multiomics analysis. Ecotoxicol Environ Saf. 2023 Aug 21;263:115393.

12. Wu S*, Huang K*, Chang C, Chu X, Zhang K, Li B# , Yang T# . Serum proteomic profiling in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2023 Jul 28;18:1623-1635.

13. Chang C, He F, Ao M, Chen J, Yu T, Li W, Li B# , Fang M# , Yang T# . Inhibition of Nur77 expression and translocation by compound B6 reduces ER stress and alleviates cigarette smoke-induced inflammation and injury in bronchial epithelial cells. Front Pharmacol. 2023 Jun 19;14:1200110.

14. He F*, Chen J*, Zhao T*, Wu Q, Yin N, Wang X, Zhong Y, Guo X, Qiu Y, Li B# , Fang M# , Wu Z# . Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular

carcinoma. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2227777

15. Li B*, Yao J*, Guo K*, He F, Chen K, Lin Z, Liu S, Huang J, Wu Q, Fang M# , Zeng J# , Wu Z# . Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. Eur J Med Chem. 2020 Oct 15;204:112608.

16. He F*, Wang X*, Wu Q, Liu S, Cao Y, Guo X, Yin S, Yin N, Li B# , Fang M# . Identification of potential ATP-competitive cyclin-dependent kinase 1 inhibitors: De novo drug generation, molecular docking, and molecular dynamics simulation. Comput Biol Med. 2023 Feb 8;155:106645.

五、学术组织兼职：

《中国药学杂志》青年编委；

《当代化工研究》编委；

“科普中国”专家；

中华预防医学会慢性病预防与控制分会委员；

北京整合医学会呼吸共病研究与转化分会常委兼秘书长；

中国研究型医院学会微生物感染与转化专业委员会青年委员；